Phosphoinositides: Functions in autophagy-related stress responses

Phosphoinositides are key lipids in eukaryotes, regulating organelles' identity and function. Their synthesis turnover require specific phosphorylation/dephosphorylation events that ensured by dedicated lipid kinases phosphatases, which modulate the structure of inositol ring adding or removing phosphates on positions 3, 4 5. Beside their implication intracellular signalization cytoskeleton dynamics, phosphoinositides essential for vesicular transport along trafficking routes, providing molecular scaffolds to membrane related such as budding, fission fusion. Robust detailed literature demonstrated some members family crucial autophagy pathway, acting fine tuners regulators. In this review, we discuss known functions canonical processes, during autophagosome formation, well importance organelle-based processes directly connected autophagic machinery, endosomal ciliogenesis innate immunity.